Atypical Antipsychotic Agents, Retinopathy, Nephropathy, and Cardiovascular Disease

Atypical antipsychotic agents, retinopathy, nephropathy, and cardiovascular disease.

Diabetes and atypical antipsychotic agents John Newcomer (St. Louis, MO) discussed changes in adiposity and insulin sensitivity with the atypical antipsychotic agents ziprasidone, risperidone, aripiprazole, quetiapine, clozapine, and olanzapine, addressing the diabetes risk seen during treatment. Among persons with schizophrenia, approximately half are obese, half to three-quarters smoke, 10– 1...

Newer oral atypical antipsychotic agents: a review.

“black-box” warnings for all antipsychotic drugs.2 Antipsychotic agents may be classified in several ways. Commonly, they can be designated as older drugs (often called conventional or “typical” antipsychotics) and newer “atypicals.” The term atypical refers to the perceived lower likelihood of extrapyramidal symptoms, a sequela that had been deemed characteristic of the first generation of ant...

Cardiovascular Disease, Neuropathy, and Retinopathy

Role of glycemia in cardiovascular disease Jacqueline Dekker (Amsterdam, the Netherlands) discussed the association between hyperglycemia and cardiovascular disease (CVD), particularly addressing A1C measurement in nondiabetic individuals. A1C, she noted, is considered a gold-standard measure of chronic glycemia in diabetic patients. In nondiabetic populations, its implications are somewhat les...

Atherosclerotic cardiovascular disease and diabetic retinopathy.

Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.

BACKGROUND Second-generation (atypical) antipsychotic drugs are widely used to treat psychosis, aggression, and agitation in patients with Alzheimer's disease, but their benefits are uncertain and concerns about safety have emerged. We assessed the effectiveness of atypical antipsychotic drugs in outpatients with Alzheimer's disease. METHODS In this 42-site, double-blind, placebo-controlled t...